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Updated: Jul 10, 2026

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Inflammation and clinical repercussions of pleurodesis induced by intrapleural talc administration
Eduardo Henrique Genofre1, Evaldo Marchi, Francisco S Vargas
1Laboratory of Pleura, Pulmonary Division - Heart Institute (InCor)-University of São Paulo Medical School, Brazil. ehgenofre@uol.com.br
Abstract:
Although reports on pleurodesis date back to the beginning of the 20th century, the search for the ideal sclerosing agent is ongoing. Several agents have been studied and used, but talc continues to be the most popular. However, potentially harmful systemic side effects have been associated with talc pleurodesis. In this article we discuss the likely mechanisms of pleural inflammation and pleurodesis with emphasis on the systemic response due to the instillation of talc into the pleural space.
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