Related Experiment Video
Updated: Jul 10, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Genetics in the context of thrombophilia
1Division of Molecular and Human Genetics, Columbus Children's Research Institute, Wexner 4, Columbus, OH 43205, USA. vargae@ccri.net
Abstract:
Traditionally, genetics is defined as the study of single-gene and chromosomal disorders, inheritance patterns and variation in organisms. Recent developments in molecular genetics have increased our understanding of how genetic traits contribute to common disease. As a result, it is anticipated that genetic technologies will increasingly be integrated into medical practice. Therefore, it is essential that all medical practitioners have an understanding of basic genetic concepts and terminology. The goal of this manuscript is to provide an overview of genetic and genomic terminology in order that health care practitioners may gain a better appreciation of how these concepts may be applied to medical practice. Factor V Leiden, a genetic alteration that results in a hypercoagulable state, is utilized to explore relevant genetic concepts.
More Related Videos
08:01The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
08:50Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
Published on: January 9, 2026
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Venous Thrombosis I: Introduction
Principles of Pharmacogenetics: Types of Genetic Variants