Related Experiment Video
Updated: Jul 10, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Positive mood and sleep disturbance in acquired mania following temporal lobe damage
June Gruber1, Julie N Lemoine, Robert T Knight
1University of California, Berkeley, CA, USA.
Primary Objective:
To determine the mood profile and sleep functioning of a patient with left anterior temporal region damage characterized by post-operative symptoms of mania.
Methods And Procedures:
In a structured clinical assessment, the patient's mood status, psychiatric diagnosis and sleep functioning - sleep onset latency, total sleep time, wake after sleep onset - were assessed. The sleep-wake cycle and daily mood was measured for 11 consecutive days.
Results:
The patient met diagnostic criteria for bipolar disorder (excluding the requirement that the disturbance must not be due to a medical disorder) and delayed sleep-phase syndrome. Across 11 days, the patient exhibited elevated positive, but not negative, mood. Correlational analyses indicated a possible association between mood and sleep disturbance.
Conclusions:
This pattern of findings implicates the temporal lobe in positive mood regulation and sleep-related impairments.
Related Concept Videos
Bipolar Disorder
Mania and Antimanic Drugs: Overview
The Influence of Affect on Cognition
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
