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Published on: March 28, 2013
Adiponectin concentrations increase during acute FFA elevation in humans treated with rosiglitazone
K Krzyzanowska1, F Mittermayer, W Krugluger
1Department of Internal Medicine I, Rudolfstiftung Hospital, Vienna, Austria. katarzyna.krzyzanowska@wienkav.at
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|October 24, 2007
Summary
Free fatty acids (FFAs) and thiazolidinediones synergistically regulate adiponectin levels in healthy subjects. This regulation depends on peroxisome proliferator-activated receptor gamma (PPAR gamma) activation, influencing adiponectin serum concentrations.
Area of Science:
- Endocrinology
- Metabolic Research
Background:
- Adiponectin, an adipocytokine, is released by adipocytes.
- Peroxisome proliferator-activated receptor gamma (PPAR gamma) activation influences adiponectin release.
- PPAR gamma has binding sites for thiazolidinediones and free fatty acids (FFAs).
Purpose of the Study:
- To investigate the in vivo synergistic regulation of adiponectin serum concentrations by FFAs and thiazolidinediones.
- To determine the role of PPAR gamma activation in mediating these effects.
Main Methods:
- Double-blind, randomized, placebo-controlled study in 16 healthy males.
- 21-day administration of rosiglitazone (a thiazolidinedione) or placebo.
- Acute elevation of plasma FFAs via intravenous triglyceride/heparin infusion.
Main Results:
- Rosiglitazone increased adiponectin and decreased FFA levels.
- Lipid infusion increased FFAs, with attenuated elevation in rosiglitazone group.
- Adiponectin concentrations significantly increased only in rosiglitazone-treated subjects post-infusion.
Conclusions:
- Acute elevation of circulating adiponectin during acutely elevated FFAs depends on PPAR gamma activation.
- Thiazolidinediones, via PPAR gamma, modulate adiponectin response to FFAs in healthy individuals.
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