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Related Experiment Video

Updated: Jul 10, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Gold complexes as prospective metal-based anticancer drugs.

V Milacic¹, D Fregona, Q P Dou

¹The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit 48201, Michigan, USA.

Histology and Histopathology

|October 24, 2007

Summary

Gold(III) dithiocarbamate complexes show anticancer activity by targeting the proteasome, inhibiting tumor growth, and inducing apoptosis in vivo. This offers a promising alternative to cisplatin chemotherapy.

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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

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Published on: May 28, 2014

Area of Science:

Medicinal Chemistry
Biochemistry
Oncology

Background:

Gold's historical medicinal use contrasts with its limited modern application.
Cisplatin, a platinum-based drug, faces challenges like toxicity and resistance.
Gold(III) complexes, structurally similar to cisplatin, are explored for anticancer potential.

Purpose of the Study:

Investigate the anticancer activity of gold(III) dithiocarbamate complexes.
Determine the molecular target of these gold compounds.
Evaluate their efficacy in a preclinical cancer model.

Main Methods:

Synthesis and characterization of gold(III) dithiocarbamate complexes.
In vitro assays to assess cytotoxicity and proteasome inhibition.
In vivo studies using human breast tumor xenografts in nude mice.

Main Results:

Gold(III) dithiocarbamates demonstrated significant anticancer effects.
The primary molecular target identified was the proteasome.
In vivo treatment led to tumor growth inhibition, proteasome suppression, and apoptosis.

Conclusions:

Gold(III) dithiocarbamates represent a novel class of anticancer agents targeting the proteasome.
These compounds offer a potential alternative to platinum-based drugs with different mechanisms.
Further research into gold compound metabolism is crucial for clinical development.