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Updated: Jul 10, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Issues with using baseline in last observation carried forward analysis
Steven A Julious1, Mark A Mullee
1Medical Statistics Group, University of Sheffield, Sheffield, UK. S.A.Julious@Sheffield.ac.uk
Abstract:
The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.
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