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[Oxidative stress in a rat model of dietary-induced obesity]
Xiuhua Shen1, Wei Cai, Qingya Tang
1Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Clinical Nutrition Center, Shanghai XinHua Hospital, Shanghai 200092, China.
Objective:
To evaluate the levels of antioxidative indexes, lipid metabolism and glycometabolism in high fat diet-induced obese rats.
Methods:
A rat model of high fat diet induced obesity was established by feeding weaning male Sprague-Dawley rats with high-fat diet for 10 weeks. plasma 8-epi-prostaglandin-F2 (8-epi-PGF2), alpha-tocopherol, superoxide dismutase activity (SOD), and glutathione peroxidase activity (GSH-Px) were detected. Parameters of lipid metabolism and glycometabolism were also tested by standard methods.
Results:
After 10 weeks, the high fat diet-induced obesity and lipid metabolism and glycometabolism disorders of obese rats (n = 10) were found. In the comparison with the control groups (n = 10), plasma 8-epi-PGF2 levels of obese rats were more higher, while plasma adjusted alpha-tocopherol (divided by plasma lipids), SOD and GSH-Px activities of obese rats were more lower.
Conclusion:
Obesity induced by high-fat feeding involves increased oxidative stress and decreased antioxidant capacity.
