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Rheumatoid arthritis antirheumatic drug trials. I. Effects of standardization procedures on observer dependent
N Bellamy1, T P Anastassiades, W W Buchanan
1Division of Rheumatology, University of Western Ontario, London, Canada.
Abstract:
A study was designed to assess the effects of standardization procedures on reducing interobserver variability for outcome measures given in the current Food and Drug Administration and European League Against Rheumatism guidelines and others selected from the rheumatology literature. Over 2 days, 6 rheumatologists independently examined 6 patients with rheumatoid arthritis (RA) in predetermined order before and after standardizing their examination techniques. An important and beneficial effect of the standardization procedure was observed on the majority of outcome variables. Such reductions in observer variability have the potential to diminish sample size requirements for antirheumatic drug studies.