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[Changes of bone density and insulin-like growth factor-1 level in elders with type 2 diabetes mellitus]
Shao-fan Zeng1, Yan Wu, Yi Wang
1Department of Endocrinology, the Second Hospital Affiliated to Chongqing University of Medical Science, Chongqing 400010, China.
Objective:
To investigate the changes of bone mineral density(BMD) and the relationship of BMD to serum Insulin-like growth factor-1 concentrations, body mass index (BMI), waist hip ratio (WHR), estradiol (E2), testosterone (T), biochemical markers of bone turnover as well as other factors in the elderly individuals with Type 2 diabetes mellitus (T2DM).
Methods:
BMDs of spine were measured by quantitative CT for patients with T2DM (n=53) and health controls (n=40). The relationships of BMD related to serum Insulin-like growth factor-1 concentrations, BMI, WHR, E2, T, bone Gla'protein, bone alkaline phosphatase, tartrate resistant acid phosphatase 5b levels were also analyzed.
Results:
The spine BMD values for the T2DM patients were significantly reduced when compared with controls [(74.75 +/- 22.70) mg/cc vs. (88.04 +/- 28.29) mg/cc, P < 0.05], and the concentration of serum Insulin-like growth factor-1 in T2DM group was significantly lower than that in control [(27.63 +/- 5.74) ng/mL vs. (32.51 +/- 9.68) ng/mL, P < 0.05]. The level of serum Insulin-like growth factor-1 was positive correlation to bone-specific alkaline phosphatase (B-ALP) in the T2DM patients (r = 0.46, P < 0.01).
Conclusion:
The spine BMD in elderly T2DM patients is lower than that in control group. The circulating serum Insulin-like growth factor-1 does not have a significant influence on bone mass in elderly T2DM patients.
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