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Related Concept Videos

Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

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Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
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Published on: September 29, 2016

Supramolecular signalling complexes in the nervous system.

M O Collins1, S G N Grant

  • 1Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom. moc@sanger.ac.uk

Sub-Cellular Biochemistry
|October 24, 2007
PubMed
Summary
This summary is machine-generated.

Multiprotein signalling complexes organize cellular pathways. This study reveals common structures in synaptic protein complexes, particularly those involving PDZ-domain scaffolds, which are crucial for neuronal function and cellular memory.

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Area of Science:

  • Cell Biology
  • Neuroscience
  • Proteomics

Background:

  • Cellular signaling relies on multiprotein complexes.
  • Synapses process electrical activity using protein components.
  • Emerging research highlights modular protein complexes at the synapse.

Purpose of the Study:

  • To overview proteomic methodologies for analyzing multiprotein complexes.
  • To characterize multiprotein complexes associated with ion channels and GPCRs.
  • To discuss common components and organization of synaptic protein complexes.

Main Methods:

  • Proteomic methods for analyzing multiprotein complexes.
  • Bioinformatic approaches to study protein organization.
  • Characterization of specific ion channel and GPCR complexes.

Main Results:

  • A common organization of synaptic protein complexes is emerging, centered on receptor/channels, protein scaffolds, and membrane-cytoskeleton interactions.
  • PDZ-domain based protein scaffolds are frequently used in neuronal protein complexes.
  • Differential protein presence in complexes can lead to functional consequences.

Conclusions:

  • Proteomic and bioinformatic analyses are vital for understanding synaptic organization.
  • Synaptic protein complexes exhibit conserved organizational principles.
  • Further investigation into these complexes can elucidate neuronal function and disease mechanisms.