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Related Experiment Video

Updated: Jul 10, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Studying Chronic Exposure of Mice to Ultraviolet B Radiation

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Targeted UVB phototherapy for psoriasis: a preliminary study.

M Lapidoth1, M Adatto, M David

  • 1Dermatological Laser Clinic, Herzliya Medical Center, Herzeliya, Israel. alapidot@netvision.net.il

Clinical and Experimental Dermatology
|October 24, 2007
PubMed
Summary

A new targeted ultraviolet (UV)B lamp effectively treats plaque psoriasis. This targeted UVB therapy shows significant Psoriasis Severity Index improvement with minimal exposure, sparing healthy skin.

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Area of Science:

  • Dermatology
  • Phototherapy
  • Laser Treatment

Background:

  • Excimer laser therapy offers good results for psoriasis at lower cumulative doses than narrowband UVB.
  • Targeted phototherapy aims to improve treatment efficacy and minimize side effects.

Purpose of the Study:

  • To evaluate the clinical effectiveness of a new targeted UVB lamp (BClear, 290-320 nm) for plaque-type psoriasis.

Main Methods:

  • Twenty-eight patients with plaque psoriasis received twice-weekly treatments with the UVB lamp for 6-18 sessions.
  • UV doses were based on minimal erythema dose (MED), ranging from 150-350 mJ/cm2.
  • Psoriasis Severity Index (PSI) was assessed every two weeks for 16 weeks.

Main Results:

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  • Mean cumulative fluence until remission was 12.63 J/cm2.
  • Mean PSI improvement peaked at 73% after 6 weeks, declining to 63% at 16 weeks.
  • After 16 weeks, 36% of patients had >75% PSI improvement, and 21% achieved complete clearance.

    • Conclusions:

    • Targeted UVB radiation with the BClear lamp is effective for plaque-type psoriasis treatment.
    • Treatment requires as few as six sessions and achieves moderately long remission.
    • Selective radiation spares healthy skin from unnecessary UV exposure.