Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychiatric or psychological treatment of depression in older adults and subsequent risk of dementia: Health and Retirement Study2012-2020.

Journal of psychiatric research·2026
Same author

Association of resilience with hemoglobin A1c among youth and young adults with youth-onset diabetes.

Annals of epidemiology·2026
Same author

Photodynamic therapy-induced anticandidal effects via reactive oxygen species generation from bisdemethoxycurcumin and potassium iodide.

Scientific reports·2026
Same author

Examining the association of maternal oral health experiences with adverse birth outcomes: findings from Virginia's PRAMS survey.

BMC oral health·2026
Same author

Supplemental Nutrition Assistance Program use and cognitive performance in middle-aged and older adults.

International journal of epidemiology·2026
Same author

Trajectories of perinatal depressive symptoms in women with overweight and obesity.

Journal of behavioral medicine·2026

Related Experiment Video

Updated: Jul 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Researching periodontitis: challenges and opportunities.

Anwar T Merchant1, Waranuch Pitiphat

  • 1Department of Clinical Epidemiology and Biostatistics, McMaster University, 1492 Barker Avenue, Burlington, Ontario, Canada. anwar.merchant@post.harvard.edu

Journal of Clinical Periodontology
|October 24, 2007
PubMed
Summary

Applying an evidence-based approach to periodontitis aetiology reveals challenges in funding and study design. Solutions are proposed to improve primary prevention research in dentistry.

More Related Videos

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
07:14

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

Related Experiment Videos

Last Updated: Jul 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
07:14

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

Area of Science:

  • Evidence-based medicine
  • Periodontitis aetiology
  • Dental research

Background:

  • The evidence-based approach significantly influences medical practice and education.
  • This paper evaluates periodontitis aetiology using evidence-based methods.
  • A comparison is made with the evidence-based study of cardiovascular disease aetiology.

Purpose of the Study:

  • To apply the evidence-based approach to periodontitis aetiology.
  • To discuss challenges and opportunities in enhancing the evidence base for periodontitis.
  • To provide solutions for improving future dental research.

Main Methods:

  • Literature review and critical analysis of evidence-based methodologies.
  • Comparative analysis of evidence generation for periodontitis versus cardiovascular disease.
  • Identification and discussion of barriers in conducting cohort studies for dental outcomes.

Main Results:

  • Evidence for medical treatments often comes from clinical trials, while primary prevention relies on cohort studies.
  • High costs impede large cohort studies for periodontitis.
  • Integrating periodontitis studies into existing cohorts is a potential solution.

Conclusions:

  • Barriers to periodontitis research include cost, outcome definition, bias prevention, data analysis, and focus on teeth vs. people.
  • Solutions are proposed to address these generic dental research challenges.
  • Improving study quality will enhance the evidence base for primary prevention in dentistry.