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Updated: Jul 10, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Adhesion molecule polymorphisms in acute renal allograft rejection.

D Khazen¹, S Jendoubi-Ayed, Y Gorgi

¹Laboratoire de recherche Immunologie de la transplantation rénale et Immuno-pathologie, Laboratoire d'Immunologie EPS Charles Nicolle, Boulevard du 9 Avril, 1006 Tunis, Tunisia.

Transplantation Proceedings

|October 24, 2007

Summary

Genetic variations in key adhesion molecules do not appear to increase the risk of acute rejection after kidney transplants. This study found no link between specific gene polymorphisms and early renal allograft failure.

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Last Updated: Jul 10, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Area of Science:

Immunogenetics
Transplantation Immunology
Molecular Biology

Background:

Acute rejection is a primary cause of early kidney transplant failure.
Adhesion molecules are crucial for immune cell activation and recruitment, leading to allograft infiltration by T cells.
Understanding genetic predispositions to rejection is vital for improving transplant outcomes.

Purpose of the Study:

To investigate the association between adhesion molecule gene polymorphisms and acute renal allograft rejection.
To analyze genetic variations in intracellular adhesion molecule (ICAM)-1, platelet endothelial cell adhesion molecule (PECAM)-1, L-selectin, and E-selectin in renal transplant recipients.

Main Methods:

Retrospective genotyping of 120 renal transplant recipients and 100 controls.
Analysis of seven nucleotide polymorphisms using allele-specific PCR-SSP and PCR-RFLP.
Categorization of recipients based on acute rejection development within six months post-transplantation.

Main Results:

No statistically significant association was found between any of the analyzed adhesion molecule gene polymorphisms and the development of acute renal allograft rejection.
Forty-one patients experienced acute rejection, while 79 had uneventful post-transplant courses.

Conclusions:

The studied adhesion molecule gene polymorphisms (ICAM-1, PECAM-1, L-selectin, E-selectin) do not appear to predispose individuals to acute renal allograft rejection.
These genetic factors may not be significant risk factors for early graft failure in renal transplant recipients.