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Related Experiment Videos

Can apparent diffusion coefficient discriminate ischemic from nonischemic livers? A pilot experimental study.

Q Liu1, D Monbaliu, K Vekemans

  • 1Abdominal Transplant Surgery, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium. Qiang.Liu@med.kuleuven.be

Transplantation Proceedings
|October 24, 2007
PubMed
Summary
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Apparent diffusion coefficient (ADC) effectively detects in vivo liver ischemia, decreasing significantly. However, ADC changes were less clear for ex vivo hypothermic machine perfusion (HMP) of ischemic livers.

Area of Science:

  • Hepatology
  • Medical Imaging
  • Ischemia Research

Background:

  • Apparent diffusion coefficient (ADC) is a magnetic resonance imaging biomarker for cerebral ischemia.
  • Hepatic ischemia assessment is crucial for liver transplantation and surgery.
  • Ex vivo hypothermic machine perfusion (HMP) is used for liver preservation.

Purpose of the Study:

  • To evaluate the utility of ADC in assessing hepatic ischemia during ex vivo HMP and in vivo.
  • To compare ADC changes in normal and ischemic porcine livers under different perfusion conditions.

Main Methods:

  • Porcine livers underwent ex vivo HMP with acellular or sanguineous preservation solutions, with or without induced warm ischemia (WI).
  • In vivo assessment involved occluding liver vessels for WI and subsequent reperfusion.

Related Experiment Videos

  • Aspartate aminotransferase (AST) levels and histology served as surrogates for WI severity.

    • Main Results:

    • In vivo ADC significantly decreased in the ischemic lobe, indicating successful ischemia detection.
    • Ex vivo ADC showed minimal differences between ischemic and non-ischemic livers during acellular perfusion.
    • Sanguineous perfusion ex vivo showed a slight, stable difference in ADC between WI and non-WI regions.

    Conclusions:

    • In vivo ADC reliably reflects hepatic ischemia, mirroring findings in cerebral ischemia.
    • ADC's effectiveness in monitoring hepatic ischemia during ex vivo HMP is less conclusive compared to in vivo assessments.