Related Experiment Video
Updated: Jul 10, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
Published on: October 20, 2023
Sphingosine 1-phosphate as a novel immune regulator of dendritic cells
1Unit of Cellular Immunology, National Institute for Infectious Diseases, IRCCS 'Lazzaro Spallanzani', Via Portuense 292, 00149 Rome, Italy. martino@inmi.it
Abstract:
Although originally described as an intracellular second messenger, sphingosine 1-phosphate (S1P) has recently been shown to be involved in several physiological and pathological functions as an extracellular mediator. S1P receptors are widely expressed and thought to regulate important functions in cell signalling. Recently, the role of S1P on the immune system has evoked great interest. In particular, several aspects of the effects on antigen-presenting cells (APCs) as dendritic cells (DC) in mice and humans have been reported. In this review, we focus on the role played by S1P on the DC system and its effects in immune-related pathological states.
More Related Videos
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
IP3/DAG Signaling Pathway

