Risk factors evaluation in some cardiovascular diseases

Area of Science:

• Cardiovascular Medicine
• Biophysics
• Haemorheology

Background:

• Cardiovascular risk factors are linked to impaired blood fluidity.
• Blood rheology, influenced by internal organization and various parameters, offers potential for diagnostic and prognostic profiling.

Purpose of the Study:

• To investigate haemorheological parameters in patients undergoing treatment for hypertension, coronary heart disease, and myocardial infarct.
• To evaluate cardiovascular risk based on specific blood rheology markers.

Main Methods:

• Assessment of plasma viscosity, whole blood viscosity, haematocrit, red cell aggregation, and red cell deformation.
• Comparative analysis of these parameters across patient groups with hypertension, coronary heart disease, and myocardial infarct.

Main Results:

• Hypertension patients showed increased plasma viscosity, whole blood viscosity, and red cell aggregation, with decreased red cell deformability.
• Coronary heart disease patients exhibited elevated plasma viscosity and red cell aggregation.
• Myocardial infarct patients, representing a more severe condition, displayed significant increases in both plasma and whole blood viscosity.
• Haematocrit levels remained unaffected across all studied groups.

Conclusions:

• Haemorheological alterations are significant in patients with hypertension, coronary heart disease, and myocardial infarct.
• Specific changes in blood viscosity and red cell properties correlate with the severity of cardiovascular conditions.
• These rheological parameters hold potential for diagnostic and prognostic applications in cardiovascular disease management.