Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variation, natural selection, and information content--a simulation.

Bernard Testa1, Andrzej J Bojarski

  • 1Department of Pharmacy, University Hospital Centre (CHUV), Rue du Bugnon 41, CH-1011 Lausanne. Bernard.Testa@chuv.ch

Chemistry & Biodiversity
|October 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyfunctionalized <i>N</i>-Arylsulfonyl Indoles: Identification of (<i>E</i>)-<i>N</i>-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1<i>H</i>-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-Based Therapy of Parkinson's Disease.

International journal of molecular sciences·2026
Same author

Chronic 5-HT7R activation drives depressive phenotypes and synaptic dysfunction.

Acta pharmacologica Sinica·2026
Same author

Fine-tuning 5-HT<sub>7</sub> receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties.

European journal of medicinal chemistry·2025
Same author

Novel Dual 5-HT<sub>7</sub> Antagonists and Sodium Channel Inhibitors as Potential Therapeutic Agents with Antidepressant and Anxiolytic Activities.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Identification of Orthosteric GABA<sub>B</sub> Receptor Ligands by Virtual Screening and <i>In Vitro</i> Validation.

ACS omega·2025
Same journal

Sterilization Activity and Mechanism of 3,4,5-Trihydroxy-biphenyl From Sorbus pohuashanensis Against Candida glabrata.

Chemistry & biodiversity·2026
Same journal

Systematic Characterization of Isoquinoline Alkaloids Constituents in Corydalis impatiens (Pall.) Fisch Based on UPLC-QTOF-MS/MS Combined With Feature-Based Molecular Networking.

Chemistry & biodiversity·2026
Same journal

Three Chromene Meroterpenoids With Potential Anti-Inflammatory Activity From Rhododendron anthopogonoides.

Chemistry & biodiversity·2026
Same journal

Engineering Alginate Membranes With Green Propolis-Coated Silver Nanoparticles for Potential Use in Wound Dressing.

Chemistry & biodiversity·2026
Same journal

LC-MS/MS-QTOF Based Phytochemical Characterization and In Vitro Pharmacological Potentials of the Endemic Variety, Humboldtia brunonis var. raktapushpa.

Chemistry & biodiversity·2026
Same journal

Leishmanicidal Potential of Eugenia pyriformis Cambess. (Myrtaceae) Leaf Extracts: Metabolomics and Mechanism of Action.

Chemistry & biodiversity·2026
See all related articles

This study simulates Neo-Darwinian evolution, showing natural selection decreases population information content while variation increases it. Their combined effects depend on relative strengths, impacting evolutionary trajectories.

Area of Science:

  • Evolutionary Biology
  • Information Theory
  • Computational Biology

Background:

  • Neo-Darwinism posits variation and natural selection drive evolution.
  • Variation introduces genetic diversity, while selection favors adapted organisms.
  • Unchecked variation can lead to randomization; selection imposes constraints.

Purpose of the Study:

  • To simulate variation and natural selection in a simplified model.
  • To analyze the relationship between evolutionary changes and population information content.
  • To quantify the impact of selection and variation on Shannon entropy.

Main Methods:

  • A simplified population model with individuals categorized into bins based on a quantifiable character.
  • Simulation of natural selection using a differential fertility factor (F).

Related Experiment Videos

  • Simulation of variation by content transfer between adjacent bins (variation factor Y).
  • Calculation of Shannon entropy (SE) for population histograms.
  • Main Results:

    • Natural selection (alone) decreased SE, increasing population information content.
    • Variation (alone) increased SE, decreasing population information content.
    • Combined selection and variation showed SE changes dependent on the relative strengths of F and Y.

    Conclusions:

    • Natural selection and variation have opposing effects on population information content.
    • The interplay between selection and variation determines the overall evolutionary information dynamics.
    • The model provides a framework for understanding evolutionary processes through an information-theoretic lens.