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Updated: Jul 10, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Topiramate for migraine prophylaxis
1York Hospital, Headache Clinic, Department of Neuroscience, Wigginton Road, York, UK. manuela.fontebasso@york.nhs.uk
Expert Opinion on Pharmacotherapy
|October 25, 2007
Summary
Topiramate is a licensed and effective antiepileptic drug for migraine prevention in the UK. Evidence shows it is safe, well-tolerated, and cost-effective for managing chronic migraine and in younger populations.
Area of Science:
- Neurology
- Pharmacology
Background:
- Topiramate is an antiepileptic drug used for migraine prevention.
- It is the only antiepileptic drug licensed for migraine prevention in the UK.
Purpose of the Study:
- To review the evidence for topiramate in migraine management.
- To highlight its efficacy, safety, tolerability, and cost-effectiveness.
Main Methods:
- Review of double-blind, placebo-controlled trials.
- Evaluation of cost-benefit analyses.
Main Results:
- Topiramate is a safe, effective, and well-tolerated migraine prophylactic.
- It is effective in chronic migraine and in childhood/adolescent migraine (unlicensed in UK).
- Topiramate demonstrates cost benefits by reducing work loss and improving quality of life.
Conclusions:
- Topiramate is a valuable therapeutic option for migraine prevention.
- Its use extends to chronic migraine and pediatric populations, offering significant health economic advantages.
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