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Phagosomal acidification: measurement, manipulation and functional consequences

B E Steinberg1, K K Huynh, S Grinstein

  • 1Cell Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8.

Biochemical Society Transactions
|October 25, 2007
PubMed
Summary

Phagosome acidification is crucial for innate and adaptive immunity, enabling pathogen destruction and antigen presentation. This process also regulates phagosome maturation, acting as a timing mechanism for immune cell function.

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