Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biophysical model of the role of actin remodeling on dendritic spine morphology.

PloS one·2017
Same author

Molecular and cellular mechanisms underlying anti-neuronal antibody mediated disorders of the central nervous system.

Autoimmunity reviews·2013
Same author

Stress and excitatory synapses: from health to disease.

Neuroscience·2013
Same author

The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma.

Oncogene·2010
Same author

Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress.

Neuropathology and applied neurobiology·2007
Same author

Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.

Neurobiology of disease·2007

Related Experiment Video

Updated: Jul 10, 2026

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture
10:17

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture

Published on: August 2, 2019

Liprin-alpha proteins: scaffold molecules for synapse maturation.

S A Spangler1, C C Hoogenraad

  • 1Department of Neuroscience, Erasmus Medical Center, P.O. Box 2040, 3000CA, Rotterdam, The Netherlands.

Biochemical Society Transactions
|October 25, 2007
PubMed
Summary

Liprin-alpha proteins are crucial scaffolding proteins that regulate synapse formation and function in the brain. These proteins recruit synaptic components and control synaptic transmission, impacting neuronal communication.

More Related Videos

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

Related Experiment Videos

Last Updated: Jul 10, 2026

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture
10:17

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture

Published on: August 2, 2019

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Synapses are vital for brain information processing and storage.
  • Synaptic plasticity underlies learning and memory.
  • Molecular mechanisms of synapse assembly are under active investigation.

Purpose of the Study:

  • To summarize the binding partners of liprin-alpha proteins.
  • To highlight factors controlling liprin-alpha function at synapses.
  • To discuss the role of liprin-alpha proteins in synapse formation and transmission.

Main Methods:

  • Literature review of biochemical, genetic, and imaging studies.
  • Analysis of protein-protein interactions involving liprin-alphas.
  • Examination of liprin-alpha roles in pre- and post-synaptic development.

Main Results:

  • Liprin-alpha proteins act as key scaffolding molecules at synapses.
  • They recruit essential synaptic proteins and regulate cargo transport.
  • Liprin-alphas are implicated in both synapse development and function.

Conclusions:

  • Liprin-alpha proteins are critical regulators of synaptic structure and function.
  • Understanding liprin-alpha interactions provides insights into neural communication.
  • Further research on liprin-alphas can illuminate mechanisms of brain plasticity.