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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

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Related Experiment Video

Updated: Jul 10, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Tuberculosis: evolution in millennia and minutes.

S H Gillespie1

  • 1Centre for Medical Microbiology, Hampstead Campus, Rowland Hill Street, London NW3 2PF, U.K. s.gillespie@medsch.ucl.ac.uk

Biochemical Society Transactions
|October 25, 2007
PubMed
Summary

Mycobacterium tuberculosis genetic variation drives evolution and adaptation. Understanding these genetic changes, including deletions and mutations, is key to combating tuberculosis (TB) and antibiotic resistance.

Area of Science:

  • Microbiology
  • Genetics
  • Evolutionary Biology

Background:

  • Tuberculosis (TB) is a major global health issue caused by Mycobacterium tuberculosis.
  • Historically, M. tuberculosis was considered genetically static, but recent research reveals significant adaptability.
  • Understanding the genetic mechanisms of M. tuberculosis is crucial for disease control.

Purpose of the Study:

  • To explore the genetic variation and evolutionary mechanisms of Mycobacterium tuberculosis.
  • To investigate how genetic changes influence the pathogenicity and adaptation of M. tuberculosis.
  • To understand the emergence of antibiotic resistance in M. tuberculosis.

Main Methods:

  • Analysis of DNA deletions in related mycobacteria species.
  • Identification of insertion sequences (e.g., IS6110) and their role in genetic variation.

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Growth of Mycobacterium tuberculosis Biofilms
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Growth of Mycobacterium tuberculosis Biofilms

Published on: February 15, 2012

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Last Updated: Jul 10, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Growth of Mycobacterium tuberculosis Biofilms
09:03

Growth of Mycobacterium tuberculosis Biofilms

Published on: February 15, 2012

  • Examination of point mutations conferring antibiotic resistance.

    • Main Results:

    • DNA deletions have led to the emergence of species like Mycobacterium bovis from the M. tuberculosis complex.
    • Insertion sequences contribute to genetic variation over shorter time scales, with some lineages showing over-representation in patients.
    • Point mutations are the primary mechanism for antibiotic resistance, often arising from pre-existent mutants favored under specific conditions.

    Conclusions:

    • Mycobacterium tuberculosis exhibits significant genetic plasticity, enabling adaptation to diverse pressures.
    • Genetic variation, driven by deletions, insertions, and mutations, underlies the pathogen's evolution and persistence.
    • Understanding these genetic dynamics is essential for developing effective strategies against tuberculosis and its resistance.