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Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Fukita Health University, School of Medicine, Toyoake, Aichi, Japan.
Aims:
A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported.
Methods:
Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone.
Results:
Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies.
Conclusions:
The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.
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