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Updated: Jun 19, 2026
06:25
Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
Published on: February 6, 2012
The chromosomal passenger complex: one for all and all for one
Sandrine Ruchaud1, Mar Carmena, William C Earnshaw
1Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.
Cell
|October 25, 2007
Summary
The chromosomal passenger complex regulates mitosis. Jeyaprakash et al. reveal its regulatory subunit structure, explaining how protein interactions target the complex during cell division.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The chromosomal passenger complex (CPC) is crucial for regulating mitosis.
- The CPC consists of Aurora B kinase and regulatory subunits: INCENP, Survivin, and Borealin.
Purpose of the Study:
- To elucidate the structural basis of CPC regulation.
- To understand how subunit interactions facilitate CPC targeting and function during mitosis.
Main Methods:
- X-ray crystallography to determine the structure of the regulatory subunit complex.
Main Results:
- The crystal structure of the INCENP-Survivin-Borealin complex was determined.
- Specific protein-protein interactions within the regulatory complex were revealed.
Conclusions:
- The revealed structure provides insights into the precise mechanisms of CPC regulation.
- Understanding these interactions is key to comprehending mitotic progression and chromosomal stability.
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