Related Experiment Video
Updated: Jul 10, 2026
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
NAPROC-13: a database for the dereplication of natural product mixtures in bioassay-guided protocols
José Luis López-Pérez1, Roberto Therón, Esther del Olmo
1Departamento de Química Farmacéutica, Facultad de Farmacia, Campus M. Unamuno, Universidad de Salamanca, Spain.
Motivation:
Although natural products represent a reservoir of molecular diversity, the process of isolating and identifying active compounds is a bottleneck in drug discovery programs. The rapid isolation and identification of the bioactive component(s) of natural product mixtures during the bioassay-guided fractionation have become crucial factors in the competition with chemical compound libraries and combinatorial synthetic efforts. In this respect, the use of spectral databases in identification processes is indispensable.
Results:
We have developed a database containing (13)C spectral information of over 6000 natural compounds, which allows for fast identifications of known compounds present in the crude extracts and provides insight into the structural elucidation of unknown compounds.
Availability:
http://c13.usal.es
