Related Experiment Video
Updated: Jul 10, 2026

08:52
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4
Iain MacArthur1, Paul B Mann, Eric T Harvill
1Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Journal of Endotoxin Research
|October 25, 2007
Abstract:
The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

