Ocular histoplasmosis due to Histoplasma farciminosum in Egyptian donkeys

In this study 19 donkeys suffering from face excoriations below the medial canthas and lesions in the lacrymal apparatus were subjected to clinical radiological and microbiological investigations. Also histopathological examination of biopsy materials from ocular lesions were made. Eleven out of 19 donkeys (57.9%) showed specific lesions in the lacrymal apparatus. Mycological examination revealed the isolation of Histoplasma cells from 10 out of 19 examined cases. The isolated Histoplasma culture, although not completely identical to H. farciminosum, was more related to this than to other Histoplasma species. Histopathological examination revealed the presence of marked tissue infiltration by lymphocytes, monocytes and macrophages. Also the fungal organism appeared as double-contoured yeast cells lying within macrophages and giant cells.