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Updated: Jul 10, 2026

Imaging Cell Interaction in Tracheal Mucosa During Influenza Virus Infection Using Two-photon Intravital Microscopy
Published on: August 17, 2018
[Influenza in children undergoing chemotherapy]
G M Goossen1, J B M van Woensel, M M van Noesel
1Emma Kinderziekenhuis AMC, afd. Kinderoncologie, Academisch Medisch Centrum/Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam.
Influenza can cause severe infections in children with cancer undergoing chemotherapy. Prompt consideration of influenza and vaccination is crucial for immunocompromised patients with neutropenic fever.
Area of Science:
- Pediatric Oncology
- Infectious Diseases
- Immunology
Background:
- Neutropenic fever is a common complication in pediatric cancer patients receiving chemotherapy.
- Immunocompromised states increase susceptibility to opportunistic infections.
- Common viral infections can lead to severe outcomes in vulnerable populations.
Observation:
- Two pediatric cancer patients presented with neutropenic fever shortly after chemotherapy.
- One patient had Hodgkin's lymphoma and recovered, while the other had a metastatic Wilms' tumour and succumbed to severe infectious complications.
Findings:
- Influenza virus infection occurred in both patients, highlighting its potential severity in this population.
- Common viruses like influenza can lead to fulminant secondary infections in immunocompromised individuals.
Implications:
- Influenza should be considered in the differential diagnosis of neutropenic fever in pediatric cancer patients.
- Influenza vaccination should be strongly considered for high-risk pediatric cancer patients to prevent severe outcomes.
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