Related Experiment Video
Updated: Jul 10, 2026
07:53
Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
Plane xanthoma associated with multiple mastocytoma.
Masaaki Matsumoto1, Mitsunori Ikeda, Motohiro Takeya
1Department of Dermatology, Kochi Medical School, Kochi, Japan. matsumo@med.kochi-u.ac.jp
Pediatric Dermatology
|October 26, 2007
Summary
A rare case of cutaneous mastocytoma in an infant transformed into plane xanthoma lesions. These yellowish plaques, characterized by foam cells, regressed spontaneously after corticosteroid treatment cessation.
Area of Science:
- Dermatology
- Pathology
- Immunohistochemistry
Background:
- Cutaneous mastocytoma is a rare neoplastic proliferation of mast cells in the skin.
- Xanthoma refers to the deposition of lipids in the skin, often associated with metabolic disorders.
Observation:
- A 5-month-old infant presented with brown macules that evolved into yellowish plaques after topical corticosteroid treatment.
- The lesions showed increased foam cells, identified as macrophages via immunohistochemistry (HAM56, CD204).
Findings:
- Histopathology revealed mast cell infiltration in early lesions and increased foam cells in later plaques.
- The yellowish plaques resembled xanthelasmoid mastocytosis but were identified as plane xanthoma associated with cutaneous mastocytoma.
- Spontaneous regression of the xanthoma lesions occurred after discontinuation of topical corticosteroids.
Implications:
- This case highlights a potential association between cutaneous mastocytoma and plane xanthoma.
- It suggests that foam cell accumulation in these lesions may be macrophage-mediated.
- The findings underscore the importance of immunohistochemical analysis for accurate diagnosis and understanding the pathogenesis of complex skin lesions.
