Financial implications of plans to combat methicillin-resistant Staphylococcus aureus (MRSA) in an orthopaedic

K Hassan1, C Koh, D Karunaratne

  • 1Department of Orthopaedics, Rotherham General Hospital Foundation Trust, Rotherham, UK. kamranhasan_4@hotmail.com

Abstract

Insights

The estimated cost of Methicillin-resistant Staphylococcus aureus (MRSA) infections in orthopaedic patients was £384,000 annually. Implementing a multifactorial approach, including screening and cohort nursing, could reduce this cost to £301,000.

Area of Science:

  • Healthcare Management
  • Infectious Disease Control
  • Orthopaedic Surgery

Background:

  • Retrospective cost analysis of MRSA infections.
  • Focus on elective and trauma orthopaedic patients.
  • Study conducted at Rotherham District General Hospital in 2005.

Purpose of the Study:

  • To calculate the financial burden of MRSA infections.
  • To evaluate the cost-effectiveness of proposed control measures.

Main Methods:

  • Analysis of 686 orthopaedic admissions over 3 months.
  • Identification of 10 patients with MRSA surgical wound infections.
  • Extrapolation of costs over a 12-month period.

Main Results:

  • MRSA infections incurred an estimated cost of £384,000 annually (excluding staff costs).
  • Proposed interventions projected to cost £301,000.

Conclusions:

  • MRSA control requires a multifaceted strategy.
  • Recommended measures include cohort nursing, universal screening, PCR diagnostics, bed ring-fencing, and separate dressing rooms.
  • The proposed solution offers a projected cost saving.

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...