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Updated: Jul 10, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging
Yi Zhang1, Bijoy Kundu, Karen D Fairchild
1Department of Radiology, The University of Virginia, 409 Lane Road, MR4 Building 1192, PO Box 801339, Charlottesville, VA 22908, USA.
Abstract:
A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4K) and 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After (64)Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.
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