Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic study on a lower-energy defibrillation method using computer simulation and cultured myocardial cell models.

A Yaguchi1, K Nagase, M Ishikawa

  • 1Tokyo Denki University, Saitama, 3500394 JAPAN.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|December 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders.

Communications medicine·2026
Same author

Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study).

ESMO open·2021
Same author

Prediction of hypotension during spinal anesthesia for elective cesarean section by altered heart rate variability induced by postural change.

International journal of obstetric anesthesia·2016
Same author

Localized NMR Mediated by Electrical-Field-Induced Domain Wall Oscillation in Quantum-Hall-Ferromagnet Nanowire.

Nano letters·2016
Same author

Comparison of Phosphate Binding Capacities of PA21, A Novel Phosphate Binder, with those of other Phosphate Binders in vitro and in vivo.

Drug research·2016
Same author

Optically Induced Nuclear Spin Polarization in the Quantum Hall Regime: The Effect of Electron Spin Polarization through Exciton and Trion Excitations.

Physical review letters·2015

This study explored a low-energy defibrillation technique using computer simulations and myocardial cell models. The research investigated spiral waves and fibrillation, suggesting optimal stimulation timing for efficient cardiac defibrillation with fewer side effects.

Area of Science:

  • Computational Biology
  • Cardiac Electrophysiology
  • Biomedical Engineering

Background:

  • Fibrillation, a life-threatening cardiac arrhythmia, necessitates effective defibrillation.
  • Current defibrillation methods can cause undesirable side effects on cardiac muscle.
  • Developing low-energy defibrillation techniques with minimal impact is crucial.

Purpose of the Study:

  • To evaluate a novel low-energy defibrillation technique.
  • To investigate the mechanisms of cardiac fibrillation, specifically spiral wave propagation.
  • To determine the efficacy of defibrillation based on stimulation timing.

Main Methods:

  • Utilized a two-dimensional computer simulation model of myocardial cells.
  • Employed a two-dimensional experimental model of myocardial sheets.

Related Experiment Videos

  • Measured excitation propagation during normal rhythm and fibrillation states.

    • Main Results:

    • Simulated and experimentally modeled spiral wave behavior during fibrillation.
    • Analyzed the impact of stimulation timing on defibrillation effectiveness.
    • Identified potential advantages of the low-energy technique.

    Conclusions:

    • The low-energy defibrillation technique shows promise for efficient cardiac rhythm restoration.
    • Stimulation timing is a critical factor in optimizing defibrillation success.
    • Further research into this technique could lead to safer and more effective cardiac treatments.