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Updated: Jul 10, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
Comparison of two and three-dimensional optical tomographic image reconstructions of human finger joints
Rong Song1, Alexander D Klose, Alexander K Scheel
1Depts. of Biomedical Engineering and Radiology at Columbia University, New York, NY 10027 USA.
Abstract:
We have developed an images reconstruction algorithm to recover spatial distribution of optical properties in human finger joints for early diagnosis and monitoring of rheumatoid arthritis (RA). An optimization method iteratively employs a light propagation and scattering coefficients distribution for near-infrared (NIR) light inside the joint tissue. We developed the differences in cross-sectional images obtained by using the reconstruction algorithms with 2-dimensional and 3-dimensional light propagation models. In particular we examined how these different approaches affect the discrimination between healthy and RA joints.
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