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Published on: December 4, 2021
Differences in pHi recovery in CO2-chemosensitive and non-chemosensitive cells: predictions from a mathematical model
Juan M Cordovez1, Chris Clausen, Leon C Moore
1Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 USA. jcordove@ic.sunysb.edu
Abstract:
In this paper, we present a mathematic model designed to identify potential mechanisms responsible for the observed differences in pHi recovery in CO(2)-chemosensitive versus non-chemosensitive cells. The model suggests that differences in pHi regulation may be dependent upon differences in the activation set-point of the internal modifier site of the Na(+)/H(+) exchanger (NHE).
