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Updated: Jul 10, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
[Expression of C-erb B-2 and its relation to angiogenesis in nasopharyngeal carcinoma]
Yi-Min Liu1, Guang-Wei Yang, Shou-Min Bai
1Department of Oncology, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Objective:
To investigate the association of C-erb B-2 expression with angiogenesis in nasopharygeal carcinoma.
Methods:
Seventy-seven specimens of nasopharygeal carcinoma were examined immunohistochemically for protein expressions of C-erb B-2 and vascular endothelial growth factor (VEGF), and the microvessel density (MVD) was determined by immunostaining of the endothelial cells for factor VIII-related antigen (F8).
Results:
Positive C-erb B-2 immunostaining was observed in 36.36% (28/77) of the nasopharygeal carcinoma tissues, which had a VEGF positivity rate of 32.48% (25/77). High positivity rate of C-erg B-2 was associated with high positivity rate of VEGF and high MVD (P<0.05).
Conclusion:
The expression of C-erb B-2 may contribute to angiogenesis in nasopharygeal carcinoma.
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