Related Experiment Videos
[Expression of LIV-1 mRNA in human cervical carcinoma and endometrial carcinoma]
1Center for Laboratory Medicine, First Affiliated Hospital of School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. zhaole@stu.xjtu.edu.cn
Objective:
To investigate the mRNA expression of oestrogen-regulated gene LIV-1 in human cervical carcinoma and endometrial carcinoma.
Methods:
RT-PCR was performed to detect the expression of LIV-1 mRNA in 49 cervical carcinoma, 11 normal cervical tissue, 24 endometrial carcinoma and 5 normal endometrial specimens.
Results:
The relative quantity of LIV-1 mRNA in normal cervical tissue, cervical carcinoma in situ and cervical carcinoma was 0.20-/+0.16, 0.31-/+0.13 and 0.40-/+0.15, respectively (P<0.05). No significant variation in LIV-1 mRNA expression was noted in relation to FIGO stages, histological differentiation, invasion depth and lymph node metastasis of the tumor (P>0.05), and LIV-1 mRNA level was similar between endometrial carcinoma and normal endometrial tissues (P>0.05).
Conclusion:
LIV-1 mRNA upregulation seems to be tissue-specific, and LIV-1 can be associated with the progression of cervical squamous cell carcinoma progression but not with the development of endometrial carcinoma.
Related Concept Videos
Non-LTR Retrotransposons
lncRNA - Long Non-coding RNAs
Uterus and Cervix
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...