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Related Experiment Videos

Household chemicals, persistent wheezing and lung function: effect modification by atopy?

J Henderson1, A Sherriff, A Farrow

  • 1Avon Longitudinal Study of Parents and Children, Dept of Community-based Medicine, 24 Tyndall Ave, University of Bristol, Bristol BS8 1BR, UK. A.J.Henderson@bris.ac.uk

The European Respiratory Journal
|October 26, 2007
PubMed
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Maternal exposure to household chemicals during pregnancy is linked to persistent wheezing and reduced lung function in nonatopic children. This association may stem from prenatal developmental or postnatal irritant effects on airways.

Area of Science:

  • Environmental Health
  • Pediatric Respiratory Medicine
  • Epidemiology

Background:

  • Maternal use of domestic chemicals during pregnancy is a potential environmental exposure.
  • The impact of household chemical exposure on child respiratory health, particularly wheezing and lung function, requires further investigation.
  • The role of atopy as a potential modifier in this relationship is not fully understood.

Purpose of the Study:

  • To evaluate the association between maternal domestic chemical exposure during pregnancy and wheezing and lung function in children up to 8.5 years old.
  • To explore whether atopy modifies the effects of domestic chemical exposure on respiratory outcomes.
  • To investigate different wheezing phenotypes (early, intermediate, late-onset) and their relationship with chemical exposure.

Main Methods:

Related Experiment Videos

  • Utilized data from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort.
  • Derived a composite household chemical exposure (CHCE) score for mothers during pregnancy.
  • Assessed wheezing phenotypes, measured lung function (FEV1, FVC, FEF25-75%), and determined atopy via skin-prick tests.

Main Results:

  • Increased CHCE score was significantly associated with early-, intermediate-, and late-onset wheezing in nonatopic children.
  • Higher CHCE scores correlated with reduced forced expiratory volume in one second (FEV1) and forced midexpiratory flow (FEF25-75%).
  • The observed associations were primarily in children without atopy, suggesting a modifying effect of atopy.

Conclusions:

  • Higher domestic chemical exposure during pregnancy is linked to persistent wheezing and impaired lung function in nonatopic children.
  • These effects may be due to prenatal developmental or postnatal irritant mechanisms affecting the developing airways.
  • The findings suggest that domestic chemical exposure, rather than increased hygiene, is a significant factor in childhood respiratory issues.