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Related Experiment Videos

External validation of a COPD diagnostic questionnaire.

D Kotz1, P Nelemans, C P van Schayck

  • 1Dept of General Practice, Maastricht University, The Netherlands. d.kotz@hag.unimaas.nl

The European Respiratory Journal
|October 26, 2007
PubMed
Summary

A new questionnaire for identifying smokers at risk of airflow limitation showed poor accuracy in distinguishing chronic obstructive pulmonary disease (COPD). This diagnostic tool is likely not useful for high-risk smokers.

Related Experiment Videos

Area of Science:

  • Pulmonary Medicine
  • Diagnostic Accuracy Studies
  • Epidemiology

Background:

  • Early detection of airflow limitation is crucial for timely intervention in smokers.
  • A novel COPD diagnostic questionnaire was developed to identify individuals at increased risk.
  • External validation is necessary to confirm the questionnaire's utility in a general population.

Purpose of the Study:

  • To assess the external validity of a new COPD diagnostic questionnaire.
  • To determine the questionnaire's ability to identify airflow limitation in smokers.
  • To evaluate the tool's diagnostic performance in a general population sample.

Main Methods:

  • A cohort of current smokers aged 40-70 years with a significant smoking history (>10 pack-years) and respiratory symptoms were recruited.
  • Spirometry, adhering to American Thoracic Society/European Respiratory Society criteria, served as the reference standard.
  • The COPD diagnostic questionnaire's discriminatory power was assessed using receiver operating characteristic (ROC) curve analysis.

Main Results:

  • The study included 676 participants; 398 had normal lung function, and 278 were diagnosed with COPD (FEV1/FVC < 0.70).
  • The COPD diagnostic questionnaire demonstrated poor performance in discriminating between subjects with and without COPD (AUC = 0.65).
  • The questionnaire's ability to identify individuals with airflow limitation was limited in this high-risk smoking population.

Conclusions:

  • The evaluated COPD diagnostic questionnaire exhibits inadequate external validity for identifying airflow limitation in middle-aged smokers.
  • The tool is likely not a reliable diagnostic aid for detecting increased risk of airflow limitation in this specific population.
  • Further research may be needed to develop more accurate screening tools for early COPD detection in smokers.