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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Impaired vascular reactivity in patients with chronic kidney disease

Fabian Tetzner1, Alexandra Scholze, Antje Wittstock

  • 1Medizinische Klinik IV, Charité Campus Benjamin Franklin, Berlin, Deutschland.

American Journal of Nephrology
|October 26, 2007
PubMed

Insights

Vascular stiffness and reactivity worsen in advanced chronic kidney disease (CKD). These arterial changes are evident even in earlier CKD stages, highlighting the need for cardiovascular monitoring in CKD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biomedical Engineering

Background:

  • Chronic kidney disease (CKD) is linked to increased cardiovascular complications.
  • Noninvasive vascular property evaluation may correlate with CKD progression and patient characteristics.

Purpose of the Study:

  • To investigate the relationship between noninvasive arterial vascular properties and different stages of chronic kidney disease (CKD).
  • To assess if vascular properties correlate with clinical and biochemical markers in CKD patients.

Main Methods:

  • Arterial vascular properties, including the reflective index, were measured using digital photoplethysmography in 260 CKD patients.
  • Patients were categorized by estimated glomerular filtration rate (eGFR) into stages 1-5.
  • Vascular reactivity was also assessed, and 50 healthy individuals served as controls.

Main Results:

  • The reflective index, indicating arterial stiffness, was significantly higher in advanced CKD stages (3-5) compared to early stages (1-2).
  • Arterial vascular reactivity was notably impaired in patients with advanced CKD (stages 3-5).
  • A significant inverse correlation was found between the reflective index and eGFR, both in univariate and multivariate analyses.

Conclusions:

  • Advanced stages of CKD are associated with increased arterial stiffness and diminished vascular reactivity.
  • These detrimental vascular changes are detectable as early as CKD stages 3 and 4.
Abstract

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