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Related Experiment Videos

Bronchoprovocation in children.

G G Shapiro1

  • 1Department of Pediatrics, University of Washington, Seattle.

Pediatrician
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Bronchial hyperresponsiveness (BHR), a key asthma trait influenced by genes and environment, can be assessed using various tests. Methacholine and histamine challenges are sensitive BHR indicators, but require careful clinical interpretation.

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Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Immunology

Background:

  • Bronchial hyperresponsiveness (BHR) is a hallmark of asthma, influenced by genetic and environmental elements.
  • Assessing BHR aids in evaluating asthma severity and treatment efficacy.

Purpose of the Study:

  • To review the assessment of bronchial hyperresponsiveness.
  • To discuss the utility and interpretation of BHR testing in asthma management.

Main Methods:

  • Review of provocative agents used for BHR assessment, including exercise, methacholine, histamine, saline solutions, and cold air.
  • Focus on the standardization and sensitivity of methacholine and histamine challenges.

Main Results:

  • BHR is a significant indicator in asthma, influenced by multiple factors.

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  • Methacholine and histamine challenges are highly sensitive but not definitive for asthma diagnosis.

    • Conclusions:

    • BHR assessment is valuable for managing asthma severity and therapy response.
    • Physicians must exercise caution when interpreting BHR test results due to potential non-specificity for asthma.