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Updated: Jul 10, 2026
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Symptomatic thromboembolism after one-stage bilateral THA with a multimodal prophylaxis protocol
Burak Beksaç1, Alejandro González Della Valle, John Anderson
1Hospital for Special Surgery and Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA.
Clinical Orthopaedics and Related Research
|October 26, 2007
Summary
This study found that aspirin and warfarin have similar effectiveness in preventing blood clots after bilateral hip replacement surgery. Both medications showed low rates of deep vein thrombosis and pulmonary embolism in patients undergoing this procedure.
Area of Science:
- Orthopedic Surgery
- Vascular Surgery
- Pharmacology
Background:
- Venous thromboembolism (VTE) is a significant risk following major orthopedic procedures.
- Optimizing chemoprophylaxis is crucial for patient safety after total hip arthroplasty (THA).
Purpose of the Study:
- To assess the incidence of VTE after one-stage bilateral total hip arthroplasties.
- To compare the efficacy of warfarin versus aspirin as chemoprophylaxis agents in this patient population.
Main Methods:
- Retrospective study of 644 patients undergoing one-stage bilateral THA.
- Patients received a multimodal prophylaxis protocol, differing only in postoperative chemoprophylaxis: warfarin (n=292) or aspirin (n=352).
- Follow-up for a minimum of 3 months to monitor for symptomatic VTE, mortality.
Main Results:
- No significant difference in symptomatic VTE, pulmonary embolism, or mortality between warfarin and aspirin groups.
- Deep vein thrombosis (DVT) incidence: 7% (warfarin) vs. 5.7% (aspirin).
- Proximal DVT: 2.39% (warfarin) vs. 2.27% (aspirin). Nonfatal pulmonary embolism: 1.36% (warfarin) vs. 1.13% (aspirin).
Conclusions:
- One-stage bilateral THA is associated with a low VTE rate using a multimodal prophylaxis protocol.
- Warfarin and aspirin demonstrate comparable efficacy in VTE prevention for patients undergoing this procedure.
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