Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The CSDH Grading Scheme for Middle Meningeal Artery Embolization: Stratified Risk of Surgical Rescue.

Neurosurgery·2026
Same author

Thrombectomy in Posterior Circulation Tandem Occlusions: Multicenter Comparative Analysis of Procedural Techniques and Predictors of Clinical Outcomes.

Radiology·2026
Same author

Stereotactic radiosurgery and dural arteriovenous fistulas: three decades of experience at the University of Pittsburgh.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same author

Decreased Risk of Severe Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in the Era of Intravenous Milrinone.

World neurosurgery·2026
Same author

Microsurgical management of tentorial dural arteriovenous fistula: an analysis from the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR).

Journal of neurosurgery·2026
Same author

Cost-Effectiveness of Adjunctive Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: Secondary Analysis of EMBOLISE.

AJNR. American journal of neuroradiology·2026

Related Experiment Video

Updated: Jul 10, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Diagnostic approach to Cushing disease.

Bradley A Gross1, Stefan A Mindea, Anthony J Pick

  • 1Department of Neurological Surgery, The Feinberg School of Medicine and McGaw Medical Center, Northwestern University, Chicago, Illinois, USA. b-gross@md.northwestern.edu

Neurosurgical Focus
|October 27, 2007
PubMed
Summary

Diagnosing Cushing disease requires a multi-step approach. Initial screening uses an 11 p.m. salivary cortisol test, followed by confirmation tests to accurately identify this adrenal hypercortisolism condition.

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Related Experiment Videos

Last Updated: Jul 10, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Cushing disease, caused by pituitary tumors, leads to adrenal hypercortisolism with significant health risks.
  • Accurate and efficient diagnosis is crucial for managing morbidity and mortality.

Purpose of the Study:

  • To outline an efficient and accurate diagnostic strategy for Cushing disease.
  • To differentiate Cushing disease from other causes of hypercortisolism.

Main Methods:

  • Initial screening with an 11 p.m. salivary cortisol level.
  • Confirmation via 24-hour urinary free cortisol and/or low-dose dexamethasone suppression tests.
  • Further differentiation using corticotropin-releasing hormone (CRH) stimulation tests and adrenocorticotropic hormone (ACTH) level assessment.
  • Pituitary magnetic resonance (MR) imaging and inferior petrosal sinus sampling for definitive diagnosis.

Main Results:

  • An 11 p.m. salivary cortisol test serves as a simple initial screening tool.
  • ACTH levels and CRH stimulation tests help distinguish between pituitary, ectopic, and adrenal causes.
  • Inferior petrosal sinus sampling is highly specific for diagnosing Cushing disease when MR imaging is equivocal.

Conclusions:

  • A stepwise diagnostic approach, starting with salivary cortisol, is effective for Cushing disease.
  • Integrating hormonal tests, imaging, and specialized procedures ensures accurate diagnosis and management.