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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Corrigendum to Correction of diabetes mellitus by transplanting minimal mass of syngeneic islets into vascularized small intestinal segment American Journal of Transplantation. Volume 13, Issue 10, October 2013, Pages 2550-2557.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
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Optimizing 3D-printed Scaffold Geometry Decreases Foreign Body Response and Enhances Allogeneic Islet Transplant Outcomes.

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Pancreatic Islet Transplantation in Extrahepatic Sites: Evaluation of the Venous Sac in Large Mammal Models.

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Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes.

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Related Experiment Video

Updated: Jul 10, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
17:42

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Allogeneic islet transplantation.

Simona Marzorati1, Antonello Pileggi, Camillo Ricordi

  • 1University of Miami Miller School of Medicine, Cell Transplant Center and Clinical Islet Transplant Program, Diabetes Research Institute, 1450 NW, 10th Avenue (R-134), Miami, FL 33136, USA.

Expert Opinion on Biological Therapy
|October 27, 2007
PubMed
Summary
This summary is machine-generated.

Islet transplantation shows promise for Type 1 diabetes, offering insulin independence and improved quality of life. Challenges like low yield and immunosuppression remain, but advancements offer optimism for this cellular therapy.

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Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
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Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

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Related Experiment Videos

Last Updated: Jul 10, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
17:42

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

A Method for Islet Transplantation to the Omentum in Mouse
06:25

A Method for Islet Transplantation to the Omentum in Mouse

Published on: January 7, 2019

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
07:36

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Published on: March 14, 2019

Area of Science:

  • Endocrinology and Metabolic Diseases
  • Cellular Therapy
  • Transplantation Immunology

Background:

  • Type 1 diabetes mellitus (T1DM) management remains a challenge, with beta-cell replacement therapies like islet transplantation offering a potential cure.
  • Islet transplantation has demonstrated success in achieving insulin independence and improving glycemic control in patients with unstable T1DM.
  • Despite progress, significant hurdles including low human islet yield and the necessity for chronic immunosuppression impede widespread adoption.

Purpose of the Study:

  • To provide a comprehensive overview of the historical advancements in islet transplantation for T1DM.
  • To highlight recent breakthroughs and ongoing challenges in beta-cell replacement therapy.
  • To discuss the potential of cellular therapies and immune interventions for T1DM cure.

Main Methods:

  • Review of historical data and clinical trial outcomes in islet transplantation.
  • Analysis of current limitations in human islet isolation and immunosuppressive strategies.
  • Exploration of emerging cellular and immune-based therapeutic approaches.

Main Results:

  • Islet transplantation can reproducibly achieve insulin independence with adequate islet cell implantation.
  • Key benefits include improved glycemic control, prevention of severe hypoglycemia, and enhanced quality of life.
  • Primary limitations are low islet yield from human pancreases and the requirement for long-term immunosuppression.

Conclusions:

  • Islet transplantation represents a significant advancement in T1DM treatment, offering functional cure potential.
  • Ongoing research into increasing islet yield and refining immune tolerance strategies is crucial.
  • The convergence of islet transplantation and novel immune interventions fuels optimism for future T1DM therapies.