Related Experiment Video
Updated: Jul 10, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
A multidrug-resistant (MDR) HIV type 1 infection in a homosexual man and identified source patient
Laura Monno1, Grazia Punzi, Gaetano Brindicci
1Clinic of Infectious Diseases, University of Bari, Bari, Italy. l.monno@clininf.uniba.it
Abstract:
We report a case (IC) of multidrug-resistant (MDR) HIV-1 infection in which the identification of the source patient (S) was supported by phylogenetic analysis of the pol gene and by the similarity of env sequences. HIV isolates from IC and S were characterized as non-syncytium viruses: a X4 variant (R(11) E(26)) was identified in both cases according to the V3 loop sequence. The pol mutational profile of IC included multiple protease and reverse-transcriptase inhibitor mutations similar to those in S. The lamivudine/tenofovir/tipranavir/ritonavir/enfuvirtide association was effective for IC but not for S.
More Related Videos
Related Concept Videos
Amebiasis
Retrovirus Life Cycles
Cryptococcal Meningitis
Sexually Transmitted Infections

