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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Heparin-induced thrombocytopenia associated with interleukin-8-dependent platelet activation in a patient with

Claire Bounameaux1, Françoise Boehlen, Aurélie Membré

  • 1Medical Department, Community Hospital of La Chaux-de-Fonds, La Chaux-de-Fonds, Switzerland. claire.bounameaux@ne.ch

European Journal of Haematology
|October 27, 2007
PubMed

Platelet factor 4 heparin enzyme immunoassay, platelet aggregation test, and serotonin release assay are commonly used to diagnose and confirm heparin-induced thrombocytopenia. We describe a case of recurrent thrombocytopenia appearing in a few hours after each heparin administration and who tested negative for the three assays. Further analysis revealed anti-interleukin (IL)-8 antibodies and IL-8-dependent platelet activation facilitated by heparin, which may explain this unusual case of heparin-induced thrombocytopenia.

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