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Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Pedigree Analysis01:35

Pedigree Analysis

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Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Probability Laws01:49

Probability Laws

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Related Experiment Video

Updated: Jul 10, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

B-vitamins, genotype and disease causality.

Paul Haggarty1

  • 1Nutrition and Epigenetics Group, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK. p.haggarty@abdn.ac.uk

The Proceedings of the Nutrition Society
|October 27, 2007
PubMed
Summary

Uncertainty about B-vitamins

Area of Science:

  • Nutritional Science
  • Genetics
  • Public Health

Background:

  • Significant uncertainty persists regarding the role of B-vitamins in health and disease.
  • Challenges in measuring intake, confounding factors in observational studies, and large trial requirements hinder definitive conclusions.
  • Genetic data, particularly Mendelian randomization, is increasingly utilized to address these limitations.

Purpose of the Study:

  • To explore the utility of genetic data in understanding B-vitamin's impact on health.
  • To discuss the integration of genetic information with traditional nutritional research.
  • To highlight the potential of genetic insights for nutrition policy formulation.

Main Methods:

  • Review of existing research on B-vitamins and genetics.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Related Experiment Videos

Last Updated: Jul 10, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

  • Discussion of Mendelian randomization as a tool for nutritional epidemiology.
  • Analysis of the interplay between diet, genotype, and health outcomes.

    • Main Results:

    • Genetic information has advanced the understanding of B-vitamin metabolism and individual responses to intake.
    • Genetic data offers potential for further nutritional insights and elucidating causal mechanisms.
    • Graphical representation of diet-genotype-health data aids in understanding genetic effects and their interactions with nutrition.

    Conclusions:

    • Genetic data is a valuable complement, not a replacement, for traditional nutritional information.
    • Understanding genotype is crucial for interpreting nutrient and biomarker status in certain experimental designs.
    • Integrated approaches using genetic and nutritional data are essential for addressing complex health and nutrition challenges.