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Updated: Jul 10, 2026
08:24
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
[Digestive diseases, intestinal infections and intussusception]
1Unité d'Hépatologie, Gastroentérologie et Nutrition Pédiatriques, Hôspital des Enfants, 330 avenue de Grande-Bretagne, TSA 70034, 31059 Toulouse cedex 9, France. mas.e@chu-toulouse.fr
Summary
New rotavirus vaccines have improved understanding of intussusception pathophysiology. Research details the causes and associated diseases of this intestinal condition.
Area of Science:
- Pediatric Gastroenterology
- Vaccine-Preventable Diseases
- Intestinal Pathophysiology
Context:
- Rotashield vaccine withdrawal highlighted intussusception risks.
- Advancements in rotavirus vaccines offer new insights.
- Understanding intussusception etiology remains crucial for public health.
Purpose:
- To review the etiopathogenic and epidemiological data of intussusception.
- To describe diseases associated with an increased risk of intussusception.
- To explore the link between rotavirus vaccines and intussusception.
Summary:
- Intussusception pathophysiology knowledge has advanced, partly due to rotavirus vaccine development.
- Idiopathic intussusception is often linked to viral or bacterial intestinal infections.
- Secondary intussusception arises from motility abnormalities in various intestinal diseases.
Impact:
- Informs vaccine safety monitoring and public health strategies.
- Aids in diagnosing and managing intussusception cases.
- Contributes to the understanding of pediatric intestinal emergencies.
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