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Updated: Jul 10, 2026

A Rat Dry Eye Model with Lacrimal Gland Dysfunction Induced by Scopolamine
Published on: February 9, 2024
[Coma with bilateral mydriasis after use of transdermal scopolamine in ICU]
X Repéssé1, T Geeraerts, J Pottecher
1Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, APHP, faculté de médecine, université Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
Abstract:
We report the case of an ICU patient with previous medical history of head trauma with hydrocephalus requiring ventricular derivation, presenting a coma (Glasgow Coma Score=8) with bilateral mydriasis after the use of transdermal scopolamine (1 mg) for profuse bronchial secretions. Neurological explorations (CT-scan and electroencephalogram) confirmed the absence of organic cause to the neurological deterioration. Neurological status rapidly and completely improved after removal of transdermal scopolamine suggesting a central anticholinergic syndrome.
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