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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Recent advances and challenges in the treatment of invasive fungal infections

Pei-Lan Shao1, Li-Min Huang, Po-Ren Hsueh

  • 1Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

International Journal of Antimicrobial Agents
|October 27, 2007
PubMed

Insights

Invasive fungal infections (IFIs) are rising, with new fungal strains showing resistance to standard treatments. Newer antifungal agents offer improved outcomes for these challenging infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Increasing incidence of invasive fungal infections (IFIs) due to growing at-risk patient populations.
  • High morbidity and mortality associated with IFIs present significant clinical challenges.
  • Shifting epidemiology of IFIs driven by antifungal prophylaxis, with emerging resistant fungal species.

Purpose of the Study:

  • To review the evolving landscape of invasive mycoses.
  • To discuss the characteristics of newly developed antifungal agents.
  • To evaluate the role of novel antifungals in managing IFIs.

Main Methods:

  • Literature review of recent studies on IFIs and antifungal agents.
  • Analysis of epidemiological trends in invasive fungal pathogens.
  • Evaluation of the properties and clinical applications of new antifungal drugs.

Main Results:

  • Emergence of non-albicans Candida, non-fumigatus Aspergillus, and other molds as significant pathogens.
  • These emerging fungi exhibit reduced susceptibility to conventional antifungal therapies.
  • Recently developed agents, including second-generation triazoles and echinocandins, show promise.

Conclusions:

  • The changing spectrum of IFIs necessitates updated treatment strategies.
  • Novel antifungal agents offer improved efficacy and safety profiles.
  • Effective management of IFIs relies on understanding emerging pathogens and utilizing advanced therapies.

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