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Synthesis of andrographolide derivatives and their TNF-alpha and IL-6 expression inhibitory activities
Jing Li1, Wenlong Huang, Huibin Zhang
1Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-alpha and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide.
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