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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Updated: Jul 10, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Brachytherapy for localised prostate cancer].

¹Département de Radiothérapie, Centre Alexis-Vautrin, 54500, Vandoeuvre-lès-Nancy Cedex, France. d.peiffert@nancy.fnclcc.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique

|October 27, 2007

Summary

Permanent prostate brachytherapy using Iodine-125 implants offers effective treatment for localized prostate cancer. This validated technique requires careful patient selection and multidisciplinary collaboration for optimal oncologic and functional outcomes.

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Area of Science:

Oncology
Radiation Oncology
Urology

Background:

Localized prostate cancer treatment options include surgery, external beam radiation, and brachytherapy.
Iodine-125 (I-125) permanent implant brachytherapy is a recognized monotherapy for select prostate cancer patients.

Purpose of the Study:

To evaluate the long-term oncologic and functional outcomes of I-125 brachytherapy for localized prostate cancer.
To highlight the importance of patient selection and precise technique in brachytherapy success.

Main Methods:

Patient selection based on favorable prognostic factors for localized prostate cancer.
I-125 permanent implant brachytherapy as monotherapy.
Multidisciplinary team approach involving radiation oncologists, urologists, and medical physicists.

Main Results:

Good 10-year oncologic outcomes confirmed preliminary findings.
Good 10-year functional outcomes demonstrated the efficacy of the technique.
Successful treatment necessitates strict patient selection and precise procedural execution.

Conclusions:

Iodine-125 brachytherapy is a validated and effective treatment for localized prostate cancer.
Close collaboration among specialists is crucial for successful brachytherapy outcomes.
Ongoing research explores new brachytherapy techniques and combinations with external beam irradiation.